Plasmin Annexin A2 and Inhibited by Inactive by Plasmin-Dependent Signaling through Metalloproteinase-1 Production Is Mediated Stimulation of Monocyte Matrix Urokinase-Type Plasminogen Activator
نویسندگان
چکیده
منابع مشابه
Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages.
Monocytes and macrophages participate in a wide variety of host defense mechanisms. Annexin II, a fibrinolytic receptor, binds plasminogen and tissue plasminogen activator (t-PA) independently at the cell surface, thereby enhancing the catalytic efficiency of plasmin production. We demonstrated previously that annexin II on the surface of both cultured monocytoid cells and monocyte-derived macr...
متن کاملPlasmin Plays an Essential Role in Amplification of Psoriasiform Skin Inflammation in Mice
BACKGROUND Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated. METHODOLOGY/PRINCIPAL FINDINGS Here we examined the contribution of plasmin to amplification of inflammation in patients with psoriasis. We found that plasminogen wa...
متن کاملCollagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity.
Matrix metalloproteinase-14 is required for degradation of fibrillar collagen by mesenchymal cells. Here we show that keratinocytes use an alternative plasminogen and matrix metalloproteinase-13-dependent pathway for dissolution of collagen fibrils. Primary keratinocytes displayed an absolute requirement for serum to dissolve collagen. Dissolution of collagen was abolished in plasminogen-deplet...
متن کاملPlasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II.
Genetic evidence demonstrates the importance of plasminogen activation in the migration of macrophages to sites of injury and inflammation, their removal of necrotic debris, and their clearance of fibrin. These studies identified the plasminogen binding protein annexin II on the surface of macrophages and determined its role in their ability to degrade and migrate through extracellular matrices...
متن کاملThromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells.
We examined the effects of thromboxane A2(TxA2) on the activities of the plasminogen-plasmin system in glomerular mesangial cells. When mesangial cells are exposed to the TxA2 agonist U-46619, a substantial increase in production of plasminogen activator inhibitor-1 (PAI-1) protein is observed that is significantly greater than that induced by 10% serum alone. This increase in PAI-1 protein pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007